Publications

Lab members are shown in bold. Preprints are included.

2026

Widespread intron retention and exon skipping characterise alternative splicing changes in a C. elegans model of spinal muscular atrophy
S. Rashid, A. Shen, A. Yong, A. Akay, M. Dimitriadi
Human Molecular Genetics, 35:ddaf176
doi:10.1093/hmg/ddaf176

2025

Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments
Z. Sultanova, A. Shen, K. Hencel, H. Carlsson, Z. Crighton, D. Clifton, A. Akay, A. A. Maklakov
Aging Cell, 24:e14481
doi:10.1111/acel.14481

NAIL-MS Elucidates Crucial tRNA U34 Modifications in Response to Heat Stress across Eukaryotes and Prokaryotes
A. M. Vicente, K. Hencel, J. Schicktanz, C. Hammann, A. Akay, S. Kaiser
Journal of Molecular Biology, 437:169228
doi:10.1016/j.jmb.2025.169228

A simple, fast and inexpensive approach using E. coli to detect and estimate vitamin B12 content in microbial extracts
K. Hencel, M. J. Sullivan, A. Akay
Biology Open, 14:bio062017
doi:10.1242/bio.062017

2024

U6 snRNA m6A modification is required for accurate and efficient splicing of C. elegans and human pre-mRNAs
A. Shen, K. Hencel, M. T. Parker, R. Scott, R. Skukan, A. S. Adesina, C. L. Metheringham, E. A. Miska, Y. Nam, W. Haerty, G. G. Simpson, A. Akay
Nucleic Acids Research, 52:9139–9160
doi:10.1093/nar/gkae447

2021

Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans
I. C. Navarro, F. Tuorto, D. Jordan, C. Legrand, J. Price, F. Braukmann, A. G. Hendrick, A. Akay, A. Kotter, M. Helm, F. Lyko, E. A. Miska
The EMBO Journal, 40:EMBJ2020105496
doi:10.15252/embj.2020105496

Toward genetic modification of plant-parasitic nematodes: delivery of macromolecules to adults and expression of exogenous mRNA in second stage juveniles
O. Kranse, H. Beasley, S. Adams, A. Pires-daSilva, C. Bell, C. J. Lilley, P. E. Urwin, D. Bird, E. Miska, G. Smant, G. Gheysen, J. Jones, M. Viney, P. Abad, T. R. Maier, T. J. Baum, S. Siddique, V. Williamson, A. Akay, S. Eves-van Den Akker
G3 GenesGenomesGenetics, 11:jkaa058
doi:10.1093/g3journal/jkaa058

The RNA polymerase II subunit RPB‐9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription
A. C. Berkyurek, G. Furlan, L. Lampersberger, T. Beltran, E. Weick, E. Nischwitz, I. Cunha Navarro, F. Braukmann, A. Akay, J. Price, F. Butter, P. Sarkies, E. A. Miska
The EMBO Journal, 40:EMBJ2020105565
doi:10.15252/embj.2020105565

2020

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
K. M. Suen, F. Braukmann, R. Butler, D. Bensaddek, A. Akay, C. C. Lin, D. Milonaitytė, N. Doshi, A. Sapetschnig, A. Lamond, J. E. Ladbury, E. A. Miska
Nature Communications, 11:4242
doi:10.1038/s41467-020-18089-1

2019

Identification of functional long non-coding RNAs in C. elegans
A. Akay, D. Jordan, I. C. Navarro, T. Wrzesinski, C. P. Ponting, E. A. Miska, W. Haerty
BMC Biology, 17:14
doi:10.1186/s12915-019-0635-7

2018

Preprints are good for science and good for the public
S. Sarabipour
Nature, 560:553–553
doi:10.1038/d41586-018-06054-4

Maintaining confidence in the reporting of scientific outputs
S. Sarabipour, E. M. Wissink, S. J. Burgess, Z. Hensel, H. Debat, E. Emmott, A. Akay, K. Akdemir, B. Schwessinger
PeerJ Preprints
doi:10.7287/peerj.preprints.27098v1

2017

The Profile and Dynamics of RNA Modifications in Animals
P. van Delft, A. Akay, S. M. Huber, C. Bueschl, K. L. M. Rudolph, T. Di Domenico, R. Schuhmacher, E. A. Miska, S. Balasubramanian
ChemBioChem, 18:979–984
doi:10.1002/cbic.201700093

The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription
A. Akay, T. Di Domenico, K. M. Suen, A. Nabih, G. E. Parada, M. Larance, R. Medhi, A. C. Berkyurek, X. Zhang, C. J. Wedeles, K. L. M. Rudolph, J. Engelhardt, M. Hemberg, P. Ma, A. I. Lamond, J. M. Claycomb, E. A. Miska
Developmental Cell, 42:241–255.e6
doi:10.1016/j.devcel.2017.07.002

2015

E. coli OxyS non-coding RNA does not trigger RNAi in C. elegans
A. Akay, P. Sarkies, E. A. Miska
Scientific Reports, 5:9597
doi:10.1038/srep09597

2013

Stress response: anything that doesn't kill you makes you stronger
A. Gartner, A. Akay
Curr. Biol.

RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let- 7 miRNA pathways in Caenorhabditis elegans
A. Akay, A. Craig, N. Lehrbach, M. Larance, E. Pourkarimi, J. E. Wright, A. Lamond, E. Miska, A. Gartner
Open Biology, 3:130151
doi:10.1098/rsob.130151

2008

Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos
H. Feitsma, A. Akay, E. Cuppen
Nucleic Acids Research, 36:4047–4056
doi:10.1093/nar/gkn341

Full list on Google Scholar